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• TapImmune Inc. changes name to Marker Therapeutics, Inc.
• To Commence Trading on NASDAQ Capital Market on Thursday, October 18, 2018 under Ticker Symbol “MRKR”
• Completes $70 million in concurrent private placement
• Company to Ring NASDAQ Stock Market Closing Bell

Jacksonville, FL, October 17, 2018 —TapImmune Inc. (NASDAQ: TPIV), today announced the closing of the previously announced merger with privately-held Marker Therapeutics, Inc. In connection with the merger, TapImmune Inc. changed its name to Marker Therapeutics, Inc., and reincorporated from Nevada into Delaware. The combined company will focus on the continued development and commercialization of T cell therapies. Beginning Thursday, October 18, 2018, the Company’s stock will begin trading under the new ticker symbol “MRKR” on the Nasdaq Capital Market and will have a new CUSIP number, 57055L 107.

“The closing of this merger marks a significant milestone, since the combined company is well-positioned to become a leader in cancer immunotherapy, with potentially transformative therapies,” said Peter L. Hoang, CEO of Marker Therapeutics, Inc. “The combined company will have exponentially superior capabilities and resources than either company had alone. With the transaction completed, we can now push our clinical trials forward more efficiently with the full resources available to the combined company. We are confident that our therapies can fundamentally improve therapeutic outcomes for patients with life-threatening diseases, and drive life-changing results for patients suffering from a variety of terrible cancers.”

Mr. Hoang continued, “In connection with the merger, we welcome to our Board of Directors, John Wilson, Dr. Juan Vera and David Eansor, whose participation and future contributions will enhance the future prospects of the combined company.”

“This merger provides Marker’s unique and highly promising T cell therapies with an excellent combination of financial support, management capacity, and scientific expertise that is expected to expedite a fundamental change in the lives of cancer patients,” said John Wilson, CEO of the former Marker Therapeutics, Inc., which changed its name to Marker Cell Therapy, Inc. in connection with the merger. “Our belief that this merger provides the best path forward has been reinforced by events surrounding the transaction, including the significant capital contribution made by highly discerning healthcare investors, led by New Enterprise Associates, the exclusive license with Baylor College of Medicine that will allow us to leverage the vast capabilities of their Center for Cell and Gene Therapy going forward, and by the willingness of Dr. James Allison (2018 Nobel Prize of Medicine recipient) and Dr. Padmanee Sharma (2018 Coley Award in Tumor Immunology recipient) to join our internationally acclaimed founders (Drs. Malcolm Brenner, Cliona Rooney, and Helen Heslop) on Marker’s Scientific Advisory Board.”

As a result of the merger, 13,914,255 shares of common stock of the Company, and warrants to purchase 5,046,003 shares of common stock at an exercise price of $2.99 per share with a five-year term, were issued to the prior stockholders of the former Marker Therapeutics, Inc., which will become a subsidiary of the combined company and renamed Marker Cell Therapy, Inc.

Concurrent with the merger, the Company closed on the previously announced private placement financing (the “Financing”). The aggregate offering size, before deducting the placement agent fees and other offering expenses, was $70 million. The Company issued 17,500,000 shares of its common stock and issued warrants to purchase 13,125,000 shares of common stock at an exercise price of $5.00 per share that will be exercisable for a period of five years. The closing of the merger and the Financing were subject to the approval of TapImmune’s stockholders as required by NASDAQ Stock Market Rules. TapImmune’s stockholders approved the issuance of the merger and Financing shares and warrants at TapImmune’s annual meeting which occurred on October 16, 2018.

The Financing proceeds will be used to advance the combined company’s novel T cell therapies into multiple Phase 2 clinical studies, build out infrastructure to support clinical and manufacturing capabilities, and other corporate and general purposes.

Piper Jaffray & Co. served as sole lead placement agent for the private placement, and Nomura Securities International, Inc. served as co-placement agent and exclusive financial advisor in conjunction with the merger.

The securities issued in the merger and sold in the Financing (together the “Securities”) have not been registered under the Securities Act of 1933, as amended, or state securities laws and may not be offered or sold in the United States absent registration with the Securities and Exchange Commission or an applicable exemption from such registration requirements. The Company has agreed to file a registration statement with the Securities and Exchange Commission covering the resale of the Securities, including the shares of common stock issuable upon exercise of the warrants. If any of the Securities are unable to be included on the initial registration statement, the Company has agreed to file subsequent registration statements until all the Securities have been registered.

As a result of the closing of the merger and the Financing, the former Marker stockholders, after taking into account the issuance of shares in the Financing occurring concurrently with the merger, now own, on a fully-diluted basis (assuming the exercise of all outstanding warrants and options), approximately 27.5%, and TapImmune’s current stockholders now own approximately 27.5%, of the Company’s common stock.

Frederick Wasserman, who was appointed Chairman of Marker’s Board upon closing of the merger said, “The completion of the merger and financing provide a strong foundation for Marker’s future growth initiatives. We are now better positioned to develop new therapies for patients and create value for our shareholders.” Mr. Wasserman continued and noted, “We look forward to working with our three new directors who are joining our Board. We also wish to recognize our former board members who left the Board in connection with the merger (Glynn Wilson, Sherry Grisewood, Mark Reddish and Joshua Silverman) for their many contributions in helping the Company reach this milestone event.”

The Company will be relocating its corporate headquarters to Houston, Texas to facilitate its collaboration with the research team at the Baylor College of Medicine. In conjunction with its move, the Company plans to open a facility in Houston to conduct its operations and oversee its clinical trials.

President & Chief Executive Officer Peter L. Hoang, accompanied by the senior management team and Board of Directors, will ring the Nasdaq Closing Bell to mark the end of trading for today, October 17th.

The ceremony, which will take place between 3:45 p.m. and 4:15 p.m. Eastern Time, will stream live online at https://new.livestream.com/nasdaq/live.

About Marker Therapeutics, Inc. (formerly TapImmune Inc.)
We are a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications. Marker’s cell therapy technology is based on the selective expansion of non-engineered, tumor-specific T cells that recognize tumor associated antigens (i.e. tumor targets) and kill tumor cells expressing those targets. Once infused into patients, this population of T cells attacks multiple tumor targets and acts to activate the patient’s immune system to produce broad spectrum anti-tumor activity. Because Marker does not genetically engineer its T cells, when compared to current engineered CAR-T and TCR-based approaches, its products (i) are significantly less expensive and easier to manufacture, (ii) appear to be markedly less toxic, and (iii) are associated with meaningful clinical benefit. As a result, Marker believes its portfolio of T cell therapies has a compelling therapeutic product profile, as compared to current gene-modified CAR-T and TCR-based therapies.

Marker is also advancing a number of innovative peptide- and gene-based immuno-therapeutics for the treatment of cancer and metastatic disease, including our Folate Receptor Alpha program (TPIV200) for breast and ovarian cancers and our HER2/neu+ peptide antigen program (TPIV100/110) in Phase II clinical trials. In parallel, we are developing a proprietary DNA expression technology named PolyStart™ to improve the ability of the cellular immune system to recognize and destroy diseased cells.

Forward-Looking Statement Disclaimer
This release contains forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995. Statements in this news release concerning the Company’s expectations, plans, business outlook or future performance, and any other statements concerning assumptions made or expectations as to any future events, conditions, performance or other matters, are “forward-looking statements”. Forward-looking statements are by their nature subject to risks, uncertainties and other factors which could cause actual results to differ materially from those stored in such statements. Such risks, uncertainties and factors include, but are not limited to any inability to recognize the anticipated benefits of the merger and the financing as well as the risks set forth in the Company’s most recent Form 10-K, 10-Q and other SEC filings which are available through EDGAR at www.sec.gov. The Company assumes no obligation to update the forward-looking statements.

CONTACTS:

Tiberend Strategic Advisors, Inc.
Joshua Drumm, Ph.D. (Investors)
(212) 375-2664
jdrumm@nulltiberend.com

David Schemelia (Media)
(212) 375-2686
dschemelia@nulltiberend.com

Marker Therapeutics, Inc.
Aaron Santos
(904) 862-6490 ext. 102
asantos@nullmarkertherapeutics.com

Jacksonville FL, October 10, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, congratulates Mayo Clinic for being awarded a grant of $11 million from the U.S. Department of Defense (DoD). This grant will cover the costs of a large Phase 2 study of TapImmune’s HER2/neu-targeted breast cancer vaccine, TPIV110, in combination with another immunotherapeutic, trastuzumab (Herceptin®), for treating women with HER2/neu-positive breast cancer.

Award recipients are Keith L. Knutson, Ph.D., Professor of Immunology in the Department of Immunology and Saranya Chumsri, M.D. in the Division of Hematology and Oncology at Mayo Clinic in Jacksonville, Florida.

TapImmune will work closely with Mayo Clinic on this clinical trial by providing clinical and manufacturing expertise as well as providing GMP vaccine formulations.

Peter L. Hoang, President and CEO of TapImmune, stated, “I am delighted that the U.S. Department of Defense has again chosen to support our technology and therapeutic platform with another funding commitment. This grant speaks to the strength and quality of the DoD’s relationship with Dr. Knutson and the Mayo Clinic. This new 380-patient trial will be the largest to date for TapImmune, and I note that the Department of Defense has now awarded almost $30 million in grants to study our novel vaccine candidates in Phase 2 clinical studies. We are grateful to the DoD for their continued efforts to support the development of new and potentially life-saving treatment modalities for women suffering from breast cancer. Like Dr. Knutson’s team at the Mayo, we believe that the underlying science indicates that TPIV110 has strong potential to synergize with Herceptin® and generate enhanced levels of protective immunity in patients with aggressive HER2-positive breast cancer.”

This is the second DoD grant to be awarded to the Mayo Clinic to study TPIV110, which is also the subject of a planned, DoD-funded Phase 2 study in women with ductal carcinoma in situ (DCIS). This newest grant also marks the third awarded to fully fund clinical trials of TapImmune’s novel peptide vaccine candidates.

Previously, TapImmune announced that the Mayo Clinic plans to conduct a Phase 2 clinical study of TPIV110 that will enroll women diagnosed with DCIS, an early form of breast cancer. If successful, the vaccine may be positioned to complement standard surgery and chemotherapy in this setting and potentially could become part of a routine immunization schedule for preventing breast cancer in healthy women.

TapImmune is also currently enrolling women into a 280-patient Phase 2 randomized, multi-center, double-blinded, placebo-controlled clinical trial of its novel therapeutic vaccine candidate TPIV200, which is funded by a $13.3 million DoD grant. This study is evaluating TPIV200 in the prevention of cancer recurrence in women with triple-negative breast cancer (TNBC) who have completed first-line surgery and radiotherapy/chemotherapy. This program is eligible for FDA Fast Track designation.

Mayo Clinic and Dr. Knutson have a financial interest in the technology referenced in this news release.

JACKSONVILLE, Florida – September 25, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that its President and CEO, Peter L. Hoang, will participate at two upcoming investor conferences. Mr. Hoang will present at the Cantor Global Healthcare Conference, to be held October 1-3, 2018, in New York City, and will present and participate in Advances in Cell and Gene Therapies Panel at the Sachs Associates 18th Annual Biotech in Europe Forum, to be held October 4-5, 2018, in Basel, Switzerland.

Cantor Global Healthcare Conference:
Date:
Monday, October 1, 2018
Location: Intercontinental New York Barclay Hotel; New York, NY
Time: 3:30pm (ET): Track 6 – Rockefeller Suite

Sachs Associates 18th Annual Biotech in Europe Forum
Date: Thursday, October 4, 2018
Location: The Congress Center Basel; Basel, Switzerland
Time: 11:30am (CEST): Panel – Advances in Cell & Gene Therapies

4:05pm (CEST): Company Presentation

Both events will be webcast, available at https://tapimmune.com/events/.

JACKSONVILLE, Florida – September 12, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that its President and CEO, Peter L. Hoang, will present at the 2018 Janney Montgomery Scott Healthcare Conference being held September 17-18, 2018, at the Union League Club in New York City. He will also be available to participate in group meetings with registered attendees.

TapImmune Company Presentation
Date: Tuesday, September 18, 2018
Time: 9:55 AM ET

An audio webcast will be accessible via the News and Events section of the TapImmune website: https://tapimmune.com/events. An archive of the audio will remain available for 90 days following the presentation.

JACKSONVILLE, Florida – August 29, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that its President and CEO, Peter L. Hoang, will participate at two upcoming industry conferences. Mr. Hoang will present and participate in a panel discussion at the Hanson Wade CAR-TCR Summit, to be held September 4-7, 2018, in Boston, Massachusetts, and present at BioCentury’s 25th Annual NewsMakers in the Biotech Industry to be held September 7, 2018, in New York City.

CAR-TCR Summit Details:
Date: Wednesday, September 5, 2018
Location: Cityview Room; Seaport Hotel and World Trade Center, Boston, MA
Time: 2:25pm (ET): Company Presentation
5:15pm (ET): Panel – How to Make CAR/TCR Therapies Work Beyond the CD19/ALL Paradigm

BioCentury Newsmakers Presentation Details:
Date: Friday, September 7, 2018
Location: Millennium Broadway Hotel & Conference Center, New York City, NY
Time: 2:30pm (ET): Presentation – Room 302/303
3:00pm (ET): Breakout Session – Room 301

Webcast: Available at https://markertherapeutics.com/events

Financing Led by New Enterprise Associates (NEA)

Financing to Close Concurrently with Close of Merger with Marker Therapeutics

JACKSONVILLE, Florida, June 8, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that it has entered into security purchase agreements with certain institutional and accredited investors in connection with a private placement of its equity securities. The private placement will be led by New Enterprise Associates (NEA) with participation from Aisling Capital and Perceptive Advisors, among other new and existing investors. The private placement is expected to be completed concurrently with the closing of the proposed merger between TapImmune Inc. and Marker Therapeutics, Inc., which was previously announced on May 15, 2018.

Upon closing the private placement, TapImmune will issue 17,500,000 shares of its common stock at a price of $4.00 per share. The aggregate offering size, before deducting the placement agent fees and other offering expenses, is expected to be $70 million. Additionally, TapImmune will issue warrants to purchase 13,125,000 shares of TapImmune common stock at an exercise price of $5.00 per share that will be exercisable for a period of five years from the date of issuance. The closing of the transaction, which is subject to the closing of the merger with Marker, the approval by TapImmune’s stockholders as required by NASDAQ Stock Market Rules, and other customary closing conditions, is anticipated to occur by the end of the third quarter of 2018.

The financing proceeds will be used to advance the combined company’s novel T cell therapy into multiple Phase 2 clinical studies, build-out the combined company’s operational and clinical facilities, and continue all ongoing and planned clinical studies for its novel T cell vaccine candidates. The financing is expected to fund the combined company into the second half of 2021.

Piper Jaffray & Co. served as sole lead placement agent for the private placement and Nomura Securities International, Inc. served as co-placement agent.

This press release is issued pursuant to Rule 135(c) under the Securities Act of 1933, as amended, and does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

The securities to be sold in the private placement have not been registered under the Securities Act of 1933, as amended, or state securities laws and may not be offered or sold in the United States absent registration with the Securities and Exchange Commission or an applicable exemption from such registration requirements. TapImmune has agreed to file a registration statement with the Securities and Exchange Commission covering the resale of the shares of common stock, including the shares of common stock issuable upon exercise of the warrants, sold in the private placement. TapImmune has agreed to file the registration statement within 15 days of the closing of the transaction. If any shares are unable to be included on the initial registration statement, TapImmune has agreed to file subsequent registration statements until all the shares have been registered, and the securities purchase agreement imposes certain customary cash penalties on TapImmune for its failure to satisfy specified filing and effectiveness time periods.

JACKSONVILLE, Florida, May 31, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that its President and CEO, Peter L. Hoang, will present at the Jefferies 2018 Global Healthcare Conference taking place June 5-8, 2018, in New York City.

TapImmune Company Presentation
Date: Thursday, June 7, 2018
Time: 3:30 PM ET

An audio webcast will be accessible via the News and Events section of the TapImmune website: https://markertherapeutics.com/events. An archive of the audio will remain available for 90 days following the presentation.

JACKSONVILLE, Florida, May 30, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that its President and CEO, Peter Hoang, will participate in a panel discussion and give a company presentation at the 2018 Sachs Associates Immuno-Oncology BD&L and Investment Forum, held June 1, 2018, at the Waldorf Astoria Chicago Hotel.

Immuno-Oncology BD&L and Investment Forum
TapImmune Company Presentation
Date: Friday, June 1, 2018
Time: 12:20 PM CT
Location: Track A

Advances in Cell & Gene Therapies Panel
Date: Friday, June 1, 2018
Time: 1:50 PM CT
Location: Track A

An audio webcast will be accessible via the News and Events section of the TapImmune website: https://markertherapeutics.com/events. An archive of the audio will remain available for 90 days following the presentation.

Jacksonville, FL – May 23, 2018 — TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, announced today that Peter Hoang, President and CEO, will host a video webinar and slide presentation to discuss the details of the proposed merger with Marker Therapeutics, Inc., on Thursday, May 24, 2018, at 4:05 p.m. EST. The webinar will be followed by a live Q&A session. To view the webinar, please visit https://www.redchip.com/events/25/tapimmune-webinar, or the events section of TapImmune’s website at https://markertherapeutics.com/events.

Mr. Hoang will discuss the details of the merger, highlighting in a slide presentation how the transaction represents the next major leap forward in cell therapy for cancer and how the opportunity could significantly disrupt the CAR-T and TCR field.

JACKSONVILLE, Florida – May 22, 2018 – TapImmune Inc. (NASDAQ: TPIV), a clinical-stage immuno-oncology company, today announced that it has expanded its recently formed Scientific Advisory Board (SAB), which will become effective in conjunction with the proposed merger between the Company and Marker Therapeutics, Inc., and will support the continued clinical development of the Company’s transformative, non-genetically engineered, multi-antigen T cell therapy platform. The new SAB members include leading experts from the University of Texas MD Anderson Cancer Center.

James P. Allison, Ph.D., is a globally recognized tumor immunologist whose research led to the clinical development of the first FDA-approved cancer immunotherapy, ipilimumab (Yervoy®). Dr. Allison is a member of the National Academy of Sciences and the Institute of Medicine, and is a fellow of the American Academy of Microbiology and the American Association for the Advancement of Science. Previously, he served as President of the American Association of Immunologists. He has received worldwide recognition for his contributions, including, the Lasker Clinical Medical Research Award, the Canada Gairdner International Award, the Szent-Györgyi Prize for Progress in Cancer Research and the Breakthrough Prize in Life Sciences for Innovative Cancer Immunology Research. Dr. Allison also serves as the Chair of MD Anderson’s Department of Immunology and Director of its Immunotherapy Platform.

Padmanee Sharma, M.D., Ph.D., is a leading translational scientist and clinical investigator focused in cancer immunotherapy. Her work was critical to advancing the research and development that yielded the world’s first checkpoint inhibitors, and she is widely regarded as one of the leading key thought leaders in immuno-oncology today.

“I am thrilled to welcome Dr. Allison and Dr. Sharma to our Scientific Advisory Board,” said Peter L. Hoang, President & CEO of TapImmune. “In many ways, Dr. Allison’s scientific contributions have made cancer immunotherapy, as we understand it today, possible. He was one of the first scientists to identify the T cell receptor – the fundamental underpinning of cell therapies and immunotherapy. His work proved cancer immunotherapy could actually drive patient responses against cancer and so, in many ways, I personally consider him to be the father of modern cancer immunotherapy. He is the recipient of many of science’s top honors, including the Lasker Prize, the Gairdner Award, the Szent-Györgyi Prize for Progress in Cancer Research and the Breakthrough Prize in Life Sciences for Innovative Cancer Immunology Research. I am honored that he has offered to contribute to the advancement of our therapies with his advice and expertise.

“Dr. Sharma is one of the top translational researchers and one of the most well-regarded oncologists in the country. Dr. Sharma made seminal discoveries in the role of the ICOS pathway in boosting the effectiveness of immunotherapy, and for years she has been a driving force in the science behind closer monitoring of tumors in various stages in order to better characterize why some patients respond to immunotherapies while others do not. She has received numerous accolades, including the 2012 MD Anderson Cancer Center Faculty Scholar Award and the 2008 Melanoma Research Alliance Young Investigator Award.”

Mr. Hoang concluded, “We’re honored that so many immunotherapy trailblazers are willing to offer their support and expertise to our company. Together with our esteemed scientific advisors we announced last week from Baylor College of Medicine’s Center for Cell and Gene Therapy, the guidance of our world-class SAB will be instrumental to our potential success. We look forward to moving ahead with their support as the proposed merger is completed.”

SAB Member Bios:

James P. Allison, Ph.D.
Dr. Allison is a Co-Founder of Jounce Therapeutics and currently serves as chair of The University of Texas MD Anderson Cancer Center Department of Immunology and director of the Immunotherapy Platform. A leading tumor immunologist, Dr. Allison has a longstanding interest in mechanisms of T cell development and activation, the development of novel strategies for tumor immunotherapy and is recognized as the first person to isolate the T cell antigen receptor protein. His research led to the clinical development of ipilimumab (Yervoy®), which was approved in 2011 by the FDA for the treatment of metastatic melanoma. Previously, he was Director of the Ludwig Center for Cancer Immunotherapy and Chair of the immunology program at the Memorial Sloan-Kettering Cancer Center, as well as the David H. Koch Chair in Immunologic Studies and attending immunologist at Memorial Sloan-Kettering Cancer Center. Dr. Allison is a member of the National Academy of Sciences and the Institute of Medicine, and is a fellow of the American Academy of Microbiology and the American Association for the Advancement of Science. Previously, he served as President of the American Association of Immunologists. He has received worldwide recognition for his contributions, including, the Lasker Clinical Medical Research Award, the Canada Gairdner International Award, the Szent-Györgyi Prize for Progress in Cancer Research and the Breakthrough Prize in Life Sciences for Innovative Cancer Immunology Research. Dr. Allison received his B.S. in microbiology and his Ph.D. in biological sciences from the University of Texas.

Padmanee Sharma, M.D., Ph.D.
A leading cancer immunotherapy translational scientist, Dr. Sharma is a Co-Founder of Jounce Therapeutics and currently serves as scientific director and professor in the departments of genitourinary medical oncology and immunology at The University of Texas MD Anderson Cancer Center. Dr. Sharma is a medical oncologist and immunologist, and is currently the principal investigator of several immunotherapy clinical trials, which allow her to further investigate immune responses and pathways that are critical for eliciting anti-tumor responses and clinical benefit in cancer patients. Dr. Sharma has received numerous awards in her field including a Department of Defense (DOD) Idea Development Award (2010), a Cancer Prevention Research Institute of Texas (CPRIT) Individual Investigator Award (2011), a National Institute of Health (NIH/NCI) R01 Award (2012) and an AACR-CRI-SU2C Immunotherapy dream team grant (2013). Dr. Sharma holds a Ph.D. in immunology and an M.D. from Pennsylvania State University. She also holds a B.A. in biology and an M.A. in biotechnology from Boston University.

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